VITAMIN K4
VITAMIN K4
CAS: 481-85-6
Molecular Formula: C11H10O2
VITAMIN K4 - Names and Identifiers
| Name | VITAMIN K4 |
| Synonyms | VITAMIN K4 2-methyl-1,4-naphthoquinol 1,4-DIACETOXY-2-METHYLNAPHTHALENE |
| CAS | 481-85-6 |
| EINECS | 207-573-8 |
VITAMIN K4 - Physico-chemical Properties
| Molecular Formula | C11H10O2 |
| Molar Mass | 174.2 |
| Density | 1.0844 (rough estimate) |
| Melting Point | 181℃ |
| Boling Point | 265.17°C (rough estimate) |
| Storage Condition | Room Temprature |
| Refractive Index | 1.525 |
| Physical and Chemical Properties | Chemical properties crystalline solids. Melting point 177-178 °c. Easily oxidized to 2-menadione. |
| Use | Use 1, 4-diacetoxy-2-methylnaphthalene, also known as vitamin K4, is an intermediate for the preparation of Vitamin K1. Vitamin K is also known as anti-bleeding vitamin, vitamin K1 can make prothrombin (Factor II) and other coagulation factors into thrombin and the corresponding factor, to achieve faster hemostasis, for bleeding caused by vitamin K deficiency, its endorphin-mediated effect is effective for biliary colic. |
VITAMIN K4 - Determination of Menadiol Diacetate Tablets by HPLC
from VIP Journal Professional Edition
Author:
Abstract:
Objective: to establish a RP-HPLC method for the determination of Menadiol Diacetate Tablets. Methods: The chromatographic column was KF-C18, with isosorbide dinitrate as internal standard, the mobile phase was Methanol-Water (65:35), the flow rate was 1.0 mL · min-1, and the detection wavelength was 224 nm. Results: the linear range of menadione acetate was 0.02~0.18 μg (r = 0.999 9). The average recovery was 99.7%,RSD was 0.4%. Conclusion: The method is accurate and reliable, and can be used for the quality analysis of the preparation.Key words:
high performance liquid chromatography menadioquinone acetate Content determination
DOI:
10.3321/j.issn:1001-5213.2005.04.050
cited:
year:
2005
Last Update：2024-01-02 23:10:35
VITAMIN K4 - Method for synthesizing methylnaphthyl hydroquinone acetate
from Palm Bridge research
Application (patent) number:
CN201110340244.0
application date:
2011-11-01
Public/Announcement Number:
CN102503818B
Public/announcement date:
2015.01.07
applicant (patent):
Anhui Wanhe Pharmaceutical Co., Ltd.
inventor:
National and provincial code:
CN341181
Abstract:
The present invention relates to a method for synthesizing methylnaphthyl hydroquinone acetate, which comprises the following steps: 2-methyl -1, 4-arylquinone is reduced to 2-methyl -1, 4-aryldiphenol by anhydrous zinc chloride and zinc acetate in the presence of HAc and then catalyzed by NaAc (CH
Last Update：2023-08-16 22:09:08
VITAMIN K4 - Determination of menadione hydroquinone acetate by flow injection chemiluminescence analysis
Author:
Yixuan Wang horse Hongyan , Zhang Xiangliang , Post , Gao Chunyan
Abstract:
Menadiol Acetate (MA), also known as vitamin K4, is a water-soluble menadione compound, which was initially used as a hemostatic drug in clinic. Is mainly used for the treatment of obstructive jaundice, biliary fistula, children Diarrhea, premature infants, neonatal low prothrombin, coumarins or salicylates excessive and other causes of prothrombin too low caused by bleeding and other diseases ~([2]), widely used in clinical practice. At present, the methods for the determination of methyl naphthyl hydroquinone acetate mainly include ultraviolet spectrophotometry, fluorescence spectrum analysis, phosphorescence analysis, high performance liquid chromatography and so on. Chemiluminescence analysis method because of its unique high sensitivity, low-cost equipment and simple operation analysis characteristics in drug analysis, environmental analysis, biochemical analysis and other fields has been
Key words:
menadioquinone acetate luminol flow injection chemiluminescence
meeting name:
Proceedings of the 18th National Symposium on organic and biological analysis of the Chinese Chemical Society
Meeting Time:
2015
meeting place:
Shanghai, China
Last Update：2023-08-16 22:09:08
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